Molecular Biology: Macromolecular Synthesis and Cellular Function

Course Description

Molecular biology of prokaryotic and eukaryotic cells and their viruses. Mechanisms of DNA replication, transcription, translation. Structure of genes and chromosomes. Regulation of gene expression. Biochemical processes and principles in membrane structure and function, intracellular trafficking and subcellular compartmentation, cytoskeletal architecture, nucleocytoplasmic transport, signal transduction mechanisms, and cell cycle control.

Lectures

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   Lecture 1 - Not your grandfathers DNA - Variations in DNA structure

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   Lecture 2 - Prokaryotic Transcription Apparatus: Part II

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   Lecture 3 - Prokaryotic Transcription Apparatus: Part I

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   Lecture 4 - The DNA replication fork: collaborate or die

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   Lecture 5 - Other replication factors: it takes a village

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   Lecture 6 - Replication origins and ends: regulation

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   Lecture 7 - You say you want a revolution: DNA analysis methods

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   Lecture 8 - DNA wrap: Chromatin and chromosome structure

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   Lecture 9 - Genome structures - what is in a model organism

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    Lecture 10 - Genomics and Bioinformatics - Time machines and function

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    Lecture 11 - Human disease genes: risky science and the new infinity

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    Lecture 12 - DNA damage and repair: oops - ouch

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    Lecture 13 - Recombination and repair in cancer

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    Lecture 14 - Control of Prokaryotic Transcription: Part I

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    Lecture 15 - Eukaryotic Transcription Apparatus and Methods to Analyze Transcription: Part I

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    Lecture 16 - Eukaryotic Transcription Apparatus and Methods to Analyze Transcription: Part II

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    Lecture 17 - Eukaryotic Transcription Apparatus and Methods to Analyze Transcription: Part III

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    Lecture 18 - Control of Eukaryotic Transcription: Part I

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    Lecture 19 - Control of Eukaryotic Transcription: Part II

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    Lecture 20 - Control of Eukaryotic Transcription: Part III

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    Lecture 21 - RNA Processing: Part I

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    Lecture 22 - RNA Processing: Part II

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    Lecture 23 - RNA Processing: Part III

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    Lecture 24 - Control of Translation: Part I

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    Lecture 25 - Control of Translation: Part II

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    Lecture 26 - Membrane Structure: Part I